Surgery for Esophageal Cancer – Improving Outcomes
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The best of the best free papers submitted for ISDE 2020 will be featured across three ISDE webinars. In the final of these, we will be concentrating primarily on peri-operative outcomes of esophagectomy for cancer through the top 8 free papers submitted on this topic. With talks ranging from evaluation of innovative surgical techniques to documentation and reporting of adverse surgical outcomes, each with expert discussion from Drs Gail Darling (Toronto) Don Low (Seattle) and Lorenzo Ferri (Montreal), this webinar from ISDE will comprehensively explore the the peri-operative surgical encounter of the esophageal cancer patient.  Complementing the free papers, Dr Don Low will deliver a state-of-the-art update on standardization of comprehensive outcomes reporting after esophagectomy. This 2-hour focused webinar will deliver what you need to keep your esophageal cancer practice up to date. 

After attending this event, the participant should be able to state the appropriate peri-operative approaches to optimize outcomes after esophageal surgery.

Effectiveness of One-Time Endoscopic Screening Program in Prevention of Esophageal Cancer in China: A Multi-Center Population-Based Cohort Study
Wenqiang Wei
China, Chinese Academy of Medical Sciences and Peking Union Medical College
Effectiveness of One-Time Endoscopic Screening Program in Prevention of Esophageal Cancer in China: A Multi-Center Population-Based Cohort Study
Esophageal cancer is one of the most common cancers worldwide and half of all new cases occurred in China. Population-based endoscopic screening has been carried out in some high-risk areas in China since 2005, but previous evidence was based predominately on small-sample, single-center studies. We undertook a population-based, multi-center cohort study to estimate the effectiveness of endoscopic screening program in reducing the incidence and mortality of esophageal in high risks areas in China.
Wenqiang Wei  
China, Chinese Academy of Medical Sciences and Peking Union Medical College
Prof. Wenqiang Wei is currently the Director of the National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. He has been engaged in cancer epidemiology and comprehensive prevention and control in high-risk areas over 20 years. As PI, he hosted 17 national / international projects focus on study etiology, primary intervention, and early detection of an Upper GI cancers through multidisciplinary and global collaborations. He has published more than 100 academic papers in professional journals such as Nature Genetics, JCO, Gut, Gastroenterology and so on.
Short-Term Outcomes of RAMIE Versus TLE For Locally Advanced Esophageal Cancer After Neoadjuvant Chemoradiotherapy: A Propensity Score-Matched Analysis
Xufeng Guo
China, Shanghai Jiaotong University
Short-Term Outcomes of RAMIE Versus TLE For Locally Advanced Esophageal Cancer After Neoadjuvant Chemoradiotherapy: A Propensity Score-Matched Analysis
This study aimed to compare the short-term outcomes of esophagectomy (RAMIE) versus thoracolaparoscopic esophagectomy (TLE) for patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer in a propensity matched cohort.
Xufeng Guo  
China, Shanghai Jiaotong University
Xu-feng Guo, M.D. is an Associate Professor at the Department of Thoracic Surgery, Section of Esophageal Surgery at Shanghai Chest Hospital, Shanghai Jiao Tong University.
Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer: Five-Year Survival Results of The MIRO Trial
Frederiek Nuytens
France, Claude Huriez University Hospital
Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer: Five-Year Survival Results of The MIRO Trial
Multiple randomized controlled trials have demonstrated the short-term benefits of (hybrid) minimally invasive esophagectomy (MIE) over open esophagectomy. Data regarding long term results are more conflicting with similar or even better results in the MIE arm. In this follow-up study of the MIRO-trial we evaluated the long-term 5-year outcomes including overall survival (OS), disease-free survival (DFS) as well as the pattern of disease recurrence, along with evaluation of potential prognostic factors affecting these outcomes.
Frederiek Nuytens  
France, Claude Huriez University Hospital
Dr. Frederiek Nuytens graduated as MD from the Catholic University of Leuven, Belgium in 2012. He completed a 6-year residency in general and abdominal surgery at the Europe Hospitals in Brussels, AZ Groeninge Hospital in Kortrijk, Zuyderland Hospital in Sittard (the Netherlands) and the University Hospital in Leuven. In 2019 he completed a fellowship in bariatric surgery at the University Hospital of Leuven. He is currently completing his surgical training as a clinical and research fellow in upper GI surgery at the University Hospital of Lille, France.
Impact of Flow Speed of ICG Fluorescence in the Gastric Conduit and Thoracic Inlet Space on Anastomotic Leakage After Esophagectomy
Kazuo Koyanagi
Japan, Tokai University School of Medicine
Impact of Flow Speed of ICG Fluorescence in the Gastric Conduit and Thoracic Inlet Space on Anastomotic Leakage After Esophagectomy
We have previously demonstrated that the flow speed of indocyanine green (ICG) fluorescence in the gastric conduit wall could predict anastomotic leakage after esophagectomy. Surround organs via retrosternal route is considered to affect the blood flow in the gastric conduit and anastomotic leakage. In the study, we investigated the impact of the flow speed of ICG fluorescence in the gastric conduit wall and thoracic inlet space on anastomotic leakage after esophagectomy.
Kazuo Koyanagi  
Japan, Tokai University School of Medicine
Dr. Kazuo Koyanagi is Associate Professor of Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Japan. Dr. Koyanagi graduated from Keio University School of Medicine, Tokyo, in 1992. He has engaged in the profession of esophageal surgical oncology and thoracoscopic minimally invasive esophagectomy. He received the degree of PhD at Keio University in 2001. He has studied abroad as a research fellow at Cornel University and John Wayne Cancer Institute from 2002 to 2005. He is a Board-Certified fellow of Japan Surgical Society and Japan Esophageal Society.
Direct Oral Feeding After a Minimally Invasive Esophagectomy: A Single-Center Prospective Cohort Study
Thijs Janssen
The Netherlands, Catharina Hospital
Direct Oral Feeding After a Minimally Invasive Esophagectomy: A Single-Center Prospective Cohort Study
A recent randomized controlled trial showed the safety and feasibility of direct oral feeding following a minimally invasive esophagectomy (MIE). However, significant differences were found regarding complication rate between hospitals, potentially influencing the effect of direct oral feeding. This study aimed to investigate the effect of direct oral feeding compared to the standard of care in a center with low anastomotic leakage and overall complication rates following a MIE.
Thijs Janssen  
The Netherlands, Catharina Hospital
Thijs Janssen has graduated as a medical doctor in August 2019 at Maastricht University. After some clinical practice he is now a researcher at the Catharina Hospital Eindhoven and PhD candidate at the University of Utrecht. His main area of research interest is decreasing (postoperative) morbidity in esophageal cancer patients undergoing an esophagectomy. His research is centered around the marginal gains theory; small incremental improvements that when all added together, may lead to more significant improvements.
Effects of Exercise Training After Esophagectomy On Physical Fitness, Quality of Life and Treatment Outcomes
Pieter de Heer
Denmark, Copenhagen University Hospital
Effects of Exercise Training After Esophagectomy On Physical Fitness, Quality of Life and Treatment Outcomes
Treatment for cancer of the gastro-esophageal junction (GEJ) can result in considerable and persistent decrements of physical fitness and health-related quality of life (HRQoL). Accordingly, a strong rationale exits to design interventions aiming at maintaining physical fitness and HRQoL during treatment. We aimed to investigate feasibility and safety of postoperative exercise training for patients with cancer of GEJ.
Pieter de Heer  
Denmark, Copenhagen University Hospital
Pieter de Heer is an UEMS accredited consultant surgeon specialized in the endoscopic and minimal invasive treatment of malignant diseases of the upper GI tract at the university hospital of Copenhagen, Denmark. His current focus of research includes pre- and postoperative optimization of patients undergoing gastrectomy, esophagectomy or pancreatectomy. The PRESET (PeRioperativE Study of Exercise Training) study is a randomized controlled trial currently including patients. The study will evaluate the effects of preoperative training on completion of therapy in patients undergoing curative resection of cancer of the stomach or GEJ
Utilizing the International Web-Based Esodata Database to Audit and Document Evolution in ECCG Complications Incidence, Definitions and Quality Measures
Madhan Kuppusamy
USA, Virginia Mason Medical Center
Utilizing the International Web-Based Esodata Database to Audit and Document Evolution in ECCG Complications Incidence, Definitions and Quality Measures
The Esophageal Complications Consensus Group (ECCG) standardized the reporting of complications associated with esophagectomy in 2015. Since then, international data on patients’ perioperative outcomes have been prospectively recorded in the web-based Esodata.org dataset. This international collaboration provides a unique opportunity to utilize a standardized reporting platform to report current esophagectomy outcomes as well as the evolution of outcomes and quality measures associated with esophagectomy over time.
Madhan Kuppusamy  
USA, Virginia Mason Medical Center
Dr. MadhanKumar Kuppusamy is the Co-Director of Minimally Invasive Thoracic Surgery at Virginia Mason Medical Center. He graduated medical school in Chennai, India and trained in General Surgery and Cardiothoracic Surgery in the United Kingdom. He obtained his Specialist Certification in Cardiothoracic Surgery from the Royal College of Physicians and Surgeons in Glasgow, United Kingdom, and has already conducted a successful and progressive career in the field of thoracic surgery before moving back to VM (more than 12 years of thoracic surgical specialist experience in the UK and USA with proven quality in surgical outcomes).
Failure to Cure in Patients Undergoing Esophageal Carcinoma Surgery: Hospital of Surgery Influences Prospects for Cure. A Nationwide Cohort Study
Daan Michiel Voeten
The Netherlands, Amsterdam University Medical Center
Failure to Cure in Patients Undergoing Esophageal Carcinoma Surgery: Hospital of Surgery Influences Prospects for Cure. A Nationwide Cohort Study
Failure to cure is a composite outcome measure that could be used for hospital comparison in surgical esophageal carcinoma care. It was first described by Clavien et al. in 1992 and was defined as the event where the procedural purpose was not fulfilled. The aim of the current study was to describe failure to cure in terms of incidence, hospital variation, and as an outcome parameter for salvage esophagectomy (surgical resection after definitive chemoradiotherapy).
Daan Michiel Voeten  
The Netherlands, Amsterdam University Medical Center
Daan M Voeten is a PhD candidate at the Dutch Institute for Clinical Auditing and the Amsterdam University Medical Center under supervision of Prof. Dr. van Berge Henegouwen and Prof. Dr. van Hillegersberg. The main focus of his work is assessment of quality of Dutch surgical upper gastrointestinal care at the Dutch Upper Gastrointestinal Cancer Audit (DUCA).
Outcomes with Respect to Esophagectomy: Where We Have Been and Where We Should Be Going
Donald Low
USA, Virginia Mason Medical Center
Outcomes with Respect to Esophagectomy: Where We Have Been and Where We Should Be Going
Donald Low  
USA, Virginia Mason Medical Center
Donald Low, MD is the Director of the Esophageal Center of Excellence at the Digestive Disease Institute, President of the Ryan Hill Research Foundation, and Chief of Thoracic Surgery and Thoracic Oncology at Virginia Mason Medical Center. Dr. Low’s clinical interests include all aspects of general Thoracic Surgery but are focused on the treatment of Esophageal Cancer, Barrett’s esophagus, benign tumors of the esophagus, primary and revisional antireflux surgery, paraesophageal hernia and achalasia. Dr. Low is a Board Certified General Thoracic Surgeon, Fellow of the American College of Surgeons and a Fellow of the Royal College of Surgeons of Canada. He has received Honorary Fellowships from the Royal College of Surgeons of Ireland, the Royal College of Surgeons of England and the Royal College of Surgeons of Edinburgh. His research interests have focused on the improvement in pathways of care associated with esophagectomy and standardizing outcome reporting and definitions associated with the surgical treatment of esophageal cancer. He is responsible for the formation of the Esophageal Complications Consensus Group (ECCG) and the International Online Esodata database and is President of the International Esodata Study Group (IESG).
Speakers
Wenqiang Wei MD
China, Chinese Academy of Medical Sciences and Peking Union Medical College
Prof. Wenqiang Wei is currently the Director of the National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. He has been engaged in cancer epidemiology and comprehensive prevention and control in high-risk areas over 20 years. As PI, he hosted 17 national / international projects focus on study etiology, primary intervention, and early detection of an Upper GI cancers through multidisciplinary and global collaborations. He has published more than 100 academic papers in professional journals such as Nature Genetics, JCO, Gut, Gastroenterology and so on.
Xufeng Guo MD
China, Shanghai Jiaotong University
Xu-feng Guo, M.D. is an Associate Professor at the Department of Thoracic Surgery, Section of Esophageal Surgery at Shanghai Chest Hospital, Shanghai Jiao Tong University.
Frederiek Nuytens MD
France, Claude Huriez University Hospital
Dr. Frederiek Nuytens graduated as MD from the Catholic University of Leuven, Belgium in 2012. He completed a 6-year residency in general and abdominal surgery at the Europe Hospitals in Brussels, AZ Groeninge Hospital in Kortrijk, Zuyderland Hospital in Sittard (the Netherlands) and the University Hospital in Leuven. In 2019 he completed a fellowship in bariatric surgery at the University Hospital of Leuven. He is currently completing his surgical training as a clinical and research fellow in upper GI surgery at the University Hospital of Lille, France.
Kazuo Koyanagi MD
Japan, Tokai University School of Medicine
Dr. Kazuo Koyanagi is Associate Professor of Department of Gastroenterological Surgery, Tokai University School of Medicine, Isehara, Japan. Dr. Koyanagi graduated from Keio University School of Medicine, Tokyo, in 1992. He has engaged in the profession of esophageal surgical oncology and thoracoscopic minimally invasive esophagectomy. He received the degree of PhD at Keio University in 2001. He has studied abroad as a research fellow at Cornel University and John Wayne Cancer Institute from 2002 to 2005. He is a Board-Certified fellow of Japan Surgical Society and Japan Esophageal Society.
Thijs Janssen MD
The Netherlands, Catharina Hospital
Thijs Janssen has graduated as a medical doctor in August 2019 at Maastricht University. After some clinical practice he is now a researcher at the Catharina Hospital Eindhoven and PhD candidate at the University of Utrecht. His main area of research interest is decreasing (postoperative) morbidity in esophageal cancer patients undergoing an esophagectomy. His research is centered around the marginal gains theory; small incremental improvements that when all added together, may lead to more significant improvements.
Pieter de Heer MD
Denmark, Copenhagen University Hospital
Pieter de Heer is an UEMS accredited consultant surgeon specialized in the endoscopic and minimal invasive treatment of malignant diseases of the upper GI tract at the university hospital of Copenhagen, Denmark. His current focus of research includes pre- and postoperative optimization of patients undergoing gastrectomy, esophagectomy or pancreatectomy. The PRESET (PeRioperativE Study of Exercise Training) study is a randomized controlled trial currently including patients. The study will evaluate the effects of preoperative training on completion of therapy in patients undergoing curative resection of cancer of the stomach or GEJ
Madhan Kuppusamy MD
USA, Virginia Mason Medical Center
Dr. MadhanKumar Kuppusamy is the Co-Director of Minimally Invasive Thoracic Surgery at Virginia Mason Medical Center. He graduated medical school in Chennai, India and trained in General Surgery and Cardiothoracic Surgery in the United Kingdom. He obtained his Specialist Certification in Cardiothoracic Surgery from the Royal College of Physicians and Surgeons in Glasgow, United Kingdom, and has already conducted a successful and progressive career in the field of thoracic surgery before moving back to VM (more than 12 years of thoracic surgical specialist experience in the UK and USA with proven quality in surgical outcomes).
Daan Michiel Voeten MD
The Netherlands, Amsterdam University Medical Center
Daan M Voeten is a PhD candidate at the Dutch Institute for Clinical Auditing and the Amsterdam University Medical Center under supervision of Prof. Dr. van Berge Henegouwen and Prof. Dr. van Hillegersberg. The main focus of his work is assessment of quality of Dutch surgical upper gastrointestinal care at the Dutch Upper Gastrointestinal Cancer Audit (DUCA).
Donald Low MD
USA, Virginia Mason Medical Center
Donald Low, MD is the Director of the Esophageal Center of Excellence at the Digestive Disease Institute, President of the Ryan Hill Research Foundation, and Chief of Thoracic Surgery and Thoracic Oncology at Virginia Mason Medical Center. Dr. Low’s clinical interests include all aspects of general Thoracic Surgery but are focused on the treatment of Esophageal Cancer, Barrett’s esophagus, benign tumors of the esophagus, primary and revisional antireflux surgery, paraesophageal hernia and achalasia. Dr. Low is a Board Certified General Thoracic Surgeon, Fellow of the American College of Surgeons and a Fellow of the Royal College of Surgeons of Canada. He has received Honorary Fellowships from the Royal College of Surgeons of Ireland, the Royal College of Surgeons of England and the Royal College of Surgeons of Edinburgh. His research interests have focused on the improvement in pathways of care associated with esophagectomy and standardizing outcome reporting and definitions associated with the surgical treatment of esophageal cancer. He is responsible for the formation of the Esophageal Complications Consensus Group (ECCG) and the International Online Esodata database and is President of the International Esodata Study Group (IESG).
Chair / Co-Chair
Daan Michiel Voeten MD
The Netherlands, Amsterdam University Medical Center
Daan M Voeten is a PhD candidate at the Dutch Institute for Clinical Auditing and the Amsterdam University Medical Center under supervision of Prof. Dr. van Berge Henegouwen and Prof. Dr. van Hillegersberg. The main focus of his work is assessment of quality of Dutch surgical upper gastrointestinal care at the Dutch Upper Gastrointestinal Cancer Audit (DUCA).
Madhan Kuppusamy MD
USA, Virginia Mason Medical Center
Dr. MadhanKumar Kuppusamy is the Co-Director of Minimally Invasive Thoracic Surgery at Virginia Mason Medical Center. He graduated medical school in Chennai, India and trained in General Surgery and Cardiothoracic Surgery in the United Kingdom. He obtained his Specialist Certification in Cardiothoracic Surgery from the Royal College of Physicians and Surgeons in Glasgow, United Kingdom, and has already conducted a successful and progressive career in the field of thoracic surgery before moving back to VM (more than 12 years of thoracic surgical specialist experience in the UK and USA with proven quality in surgical outcomes).
Lorenzo Ferri MD
Co-chair/Moderator
Canada, McGill University
Gail Darling MD
Co-chair/Moderator
Canada, University of Toronto
Donald Low MD
Co-chair/Moderator
USA, Virginia Mason Medical Center


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